Parasite stage-specific T cell responses were studied in Indians with lymphatic filariasis
manifesting as elephantiasis (CP, n= 11) and asymptomatic microfilaremia (MF, n= 8), using
antigens derived from the microfilarial, adult male only, and mixed adult male and female
worms. Proliferative responses to microfilarial and mixed (male–female adult worm)
antigens in MF individuals were markedly impaired compared to corresponding responses
in individuals with CP. In contrast, T cell proliferative responses to adult male-derived …