Cellular senescence determines endothelial cell damage induced by uremia
J Carracedo, P Buendía, A Merino, S Soriano… - Experimental …, 2013 - Elsevier
Renal dysfunction is closely associated with endothelial damage leading to cardiovascular
disease. However, the extent to which endothelial damage induced by uremia is modulated
by aging is poorly known. Aging can render endothelial cells more susceptible to apoptosis
through an oxidative stress-dependent pathway. We examined whether senescence-
associated to oxidative stress determines the injury induced by the uremia in endothelial
cells. Human umbilical vein endothelial cells (HUVEC) was incubated with human uremic …
disease. However, the extent to which endothelial damage induced by uremia is modulated
by aging is poorly known. Aging can render endothelial cells more susceptible to apoptosis
through an oxidative stress-dependent pathway. We examined whether senescence-
associated to oxidative stress determines the injury induced by the uremia in endothelial
cells. Human umbilical vein endothelial cells (HUVEC) was incubated with human uremic …
