A swimming-based assay to determine the exercise capacity of adult zebrafish cardiomyopathy models

X Ma, X Xu - Bio-protocol, 2021 - bio-protocol.org
Exercise capacity, measured by treadmill in humans and other mammals, is an important
diagnostic and prognostic index for patients with cardiomyopathy and heart failure. The adult
zebrafish is increasingly used as a vertebrate model to study human cardiomyopathy due to
its conserved cardiovascular physiology, convenience for genetic manipulation, and
amenability to high-throughput genetic and compound screening. Owing to the small size of
its body and heart, new phenotyping assays are needed to unveil phenotypic traits of …