HLA-DQA1 and PLCG2 are candidate risk loci for childhood-onset steroid-sensitive nephrotic syndrome
Steroid-sensitive nephrotic syndrome (SSNS) accounts for> 80% of cases of nephrotic
syndrome in childhood. However, the etiology and pathogenesis of SSNS remain obscure.
Hypothesizing that coding variation may underlie SSNS risk, we conducted an exome array
association study of SSNS. We enrolled a discovery set of 363 persons (214 South Asian
children with SSNS and 149 controls) and genotyped them using the Illumina HumanExome
Beadchip. Four common single nucleotide polymorphisms (SNPs) in HLA-DQA1 and HLA …
syndrome in childhood. However, the etiology and pathogenesis of SSNS remain obscure.
Hypothesizing that coding variation may underlie SSNS risk, we conducted an exome array
association study of SSNS. We enrolled a discovery set of 363 persons (214 South Asian
children with SSNS and 149 controls) and genotyped them using the Illumina HumanExome
Beadchip. Four common single nucleotide polymorphisms (SNPs) in HLA-DQA1 and HLA …
